Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression

Table 1 Clinical correlation of YAP and SERT expression in human colorectal cancer

Clinicopathologic features	Number of patients	YAP positive (%)	P value	SERT positive (%)	P Value
Age			0.665		0.890
≤ 60	24	21 (87.5)		19 (79.2)
> 60	32	22 (68.8)		20 (62.5)
Sex			0.680		0.747
Male	31	27 (87.1)		20 (64.5)
Female	25	16 (64.0)		19 (76.0)
Tumour status			0.010*		0.149
T1–2	23	19 (82.6)		18 (78.3)
T3–4	33	24 (72.7)		21 (63.6)
Nodal status			0.004**		0.002**
N0	15	7 (46.7)		5 (33.3)
N1	17	14 (82.4)		13 (76.5)
N2	24	22 (91.7)		21 (87.5)
Metastasis			0.314		0.054
M0	50	40 (80.0)		36 (0.72)
M1	6	3 (50.0)		3 (50.0)
Tumour location			0.900		0.278
Right	20	16 (80.0)		15 (75.0)
Left	23	17 (73.9)		16 (69.6)
Rectum	13	10 (76.9)		8 (61.2)
Tumour size (cm)			0.025*		0.042*
≤ 3.0	22	14 (63.6)		13 (59.1)
> 3.0	34	29 (85.3)		26 (76.5)
TNM stage			0.009**		0.002**
I	4	2 (50.0)		1 (25.0)
II	11	5 (45.5)		3 (27.3)
III	35	33 (94.3)		31 (88.6)
IV	6	3 (50.0)		4 (66.7)
Differentiation			0.326		0.454
Well	5	2 (40.0)		3 (60.0)
Moderately	34	25 (73.5)		22 (64.7)
Poorly	17	16 (94.1)		14 (82.4)

ISSN: 1478-811X