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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression

Fig. 7

Schematic representation of the proposed mechanism by which 5-HT modulates signalling pathways in colon cancer. A In colon cancer cells, extracellular 5-HT is transported into cells by SERT located in the cytomembrane and then transamidates and activates RhoA via serotonylation regulated by TG2. Subsequently, ROCK1/2 is activated, leading to the expression of YAP and its target proteins. B When SERT function is blocked by specific antagonists (such as citalopram), 5-HT intracellular transportation is weakened to some degree, blocking the cellular signalling transduction and colon cancer cell proliferation induced by 5-HT. This strategy suggests that targeting 5-HT signalling may be feasible for treating colon cancer

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Cell Communication and Signaling

ISSN: 1478-811X