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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression

Fig. 4

ROCK1/2 but not Lats1/2 mediates 5-HT-induced YAP expression in colon cancer cells. A A western blot test was used to analyse YAP and Cyr61 expression in cells treated with 10 μM 5-HT. This procedure was done after Lats1 expression was knocked down in SW480 and SW1116 cells. B After Lats2 expression was knocked down in SW480 and SW1116 cells, YAP and Cyr61 expressions in cells treated with 10 μM 5-HT were analysed by western blot. C Cells were treated with ROCK1/2 antagonists Y27632 or SLx-2119 (10 μM) for 2 h before 10 μM 5-HT stimulation; a western blot was performed to detect the expression of YAP and Cyr61 in SW480 and SW1116 cells

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Cell Communication and Signaling

ISSN: 1478-811X