Fig. 3From: Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic reviewRelationship between JAK2/STAT3 signaling pathway and Osteoarthritis. Obesity, mechanical stress, and aging are risk factors for OA. The JAK2/STAT3 signaling pathway modifies the pathological process of OA by regulating related cytokines. ↑: up-regulation (Created with BioRender.com.)Back to article page