Fig. 2From: Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic reviewThe JAK2/STAT3 signaling pathway interplayed with other signaling pathways in chondrocytes. Phosphorylated STAT3, activated by JAK2, is translocated to the nucleus, and interacting with NF-kB, AKt/PI3K, and MAPK signaling pathways, which are involved in articular cartilage degradation. (Created with BioRender.com.)Back to article page