Fig. 1From: Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic reviewThe pathology of osteoarthritis. The pathology of OA is typically characterized by articular cartilage degeneration, subchondral bone sclerosis and synovial lesions. Cartilage degradation is caused by programmed cellular death (apoptosis, proliferation, and autophagy) or inflammatory response. ↑: up-regulation;↓: down-regulation (Created with BioRender.com.)Back to article page