Table 2 Studies reporting on radioprotective effects exerted by CAFs (non-irradiated)
From: Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists?
Ref. | Fibroblast type | Tumor model | Exp model | Effects |
|---|---|---|---|---|
Chu [89] | CAFs (primary cultures) | Cervical cancer | In vitro co-cultures | Enhanced radio-resistance of Hela cells by conditioned medium from iCAF/tumor cell co-cultures, but not from iCAF monocultures |
Hwang [90] | PSC/CAFs (immortalized) | Pancreatic cancer | In vitro supernatants | CAF-CM increase radioprotection of tumor cells. Unknown soluble factor |
Wang [92] | NFs/CAFs (primary cultures) | Melanoma Lung cancer | In vitro In vivo (co-inject) | ↑IGF-1, ↑CXCL12 iCAF-mediated induction of autophagy; increased ROS in tumor cells |
Zhang [93] | Murine CAFs artificially induced radio-resistance | Prostate cancer | In vitro | Gene sequencing. Differentially expressed genes in radioresistant CAFs. Gene-signatures from radioresistant CAFs as predictors |
Ji [91] | CAFs (primary cultures) | NSCLC | In vitro (co-cultures) | CAF-induced increased radio-resistance of tumor cell lines in vitro |
Ebbing [94] | CAFs from EAC tumors | Esophageal cancer (EAC) | Human organoids Xenograft (co-inject) | Stromal IL-6 mediate therapy resistance EMT induction from CAFs. Circulating ADAM12-levels correlate with IL-6 expression by CAFs and bad prognosis |