Fig. 9From: P38 MAPK activated ADAM17 mediates ACE2 shedding and promotes cardiac remodeling and heart failure after myocardial infarctionGraphical summary. Our findings highlight the potential translational value of ADAM17 as an early warning biomarker of post-MI HF. ADAM17 activated by P38MAPK promotes the hydrolytic shedding of the cardiomyocyte transmembrane protein ACE2 and mediated the development of cardiac remodelingBack to article page