Table 1 Syncytin-1 expression in cancer
From: Intrinsic signalling factors associated with cancer cell-cell fusion
Cancer type | Fusogen/ cell | Fusogen receptor/ cells | Effect on cancer progression | References |
|---|---|---|---|---|
Breast cancer (cells) | Syncytin-1/ Breast cancer cells | ASCT2/ HUVEC | Cell fusion was correlated with improved prognosis | |
SyHP/ Breast cancer cells | Not analysed | PGCC formation | [29] | |
Breast epithelial cells | Syncytin-1/ Syncytin-2/ Breast cancer cells | ASCT2/ MSFD2A/ MSC | Not investigated | [121] |
Colon cancer cells | Syncytin-1, CD9, CD47/ Colon cancer cells | Not analysed | PGCC formation | [27] |
Syncytin-1/ Colon cancer cells | Not analysed | Overall disease progression | [32] | |
Endometrial cancer (cells) | Syncytin-1/ Endometrial cancer cells | Not analysed | Cell-cell fusion; Proliferation; invasion | |
NSCLC | Syncytin-1/ NSCLC cells | Not known/ NSCLC cells | Overall disease progression | [31] |
OSCC cells | Syncytin-1/ OSCC cells | ASCT2/ HUVEC | Cell-cell fusion | [30] |
prostate cancer (cells) | Syncytin-1/ Prostate cancer cells | Not known/ Skeletal/ smooth muscle cells | Cell-cell fusion | [28] |
seminomas | Syncytin-1/ Seminoma cells | Not analysed | Not analysed | [33] |
UCC | Syncytin-1/ UCC | Not known/ UCC | Cell-cell fusion; Proliferation | [25] |