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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer

Fig. 2

Schematic diagram of EGFR molecular domains a Domain of human EGFR and exons encoding it. It locates on chromosome 7, which consists of 28 exons. It consists of an extracellular domain, a hydrophobic transmembrane domain (TM domain), a juxtamembrane domain (JM domain), an intracellular protein tyrosine kinase domain that binds ligands and a C-terminal. b EGFR molecular structure and common EGFR-dependent drug resistance mutation sites, including L858R mutation, T790 M' gatekeeper' mutation and tertiary mutation such as C797S

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Cell Communication and Signaling

ISSN: 1478-811X