RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

Table 1 The physiological function of m6A RNA methylation in female reproductive system

Physiological function	m⁶A regulator	Type	Mechanism	References
Germ cell development	YTHDC1	Reader	Change 3'UTR length by extensive alternative polyadenylation	[57]
	YTHDC2	Reader	Influence translation efficiency and stabilize its targets	[37]
	YTHDF1	Reader	Associated with self-renewal of female mouse germline stem cells	[59]
	YTHDF2	Reader	Post-transcriptionally regulate transcript degradation during mouse oocyte meiosis	[60]
	METTL3	Writer	Interact with Itsn2 to act on oocyte meiosis in an m⁶A-dependent manner and involved in producing first polar bodies and normal spindles	[61, 62]
	IGF2BP2/IGF2BP3	Reader	Stabilize maternal mRNAs involved in DNA repair and meiosis during oogenesis	[61]
Embryo development	METTL3	Writer	Associated with the expression of naïve pluripotency transcripts	[73]
	IGF2BP3	Reader	Deficiency speeds up the degradation of maternal RNA	[74]
	IGF2BP2	Reader	Strengthen the ability of embryos to develop into blastocysts	[75]
	METTL5	Writer	Improve pluripotency of mouse embryonic stem cells and promote germ layer specification	[77]
Foetal growth	FTO	Eraser	Regulate the genes that control nutrient metabolism	[79, 82]

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