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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy

Fig. 2

Schematic diagram of the mechanism of Nrf2/Keap1/ARE signaling pathway. Nrf2 has seven homodomains, Neh1–7. Keap1 has five domains containing NTR, BTB, IVR, DGR, and CTR. Nrf2 binds to the DGR domain of keap1 homodimer via the DLG and ETGE fragments, and Cul3 binds to the BTB domain of Keap1. Under basal conditions, Nrf2 is ubiquitinated and degraded by the Keap1-Cul3 complex, without generating biological activity. Upon stimulated, Nrf2 dissociates from the Keap1-Nrf2 complex, ectopically into the nucleus and binds to sMaf, and Nrf2-sMaf binds to ARE to promote the expression of antioxidant genes, such as NQO-1, SOD, GPX, HO-1. Nrf2: Nuclear factor E2-related factor 2, Keap1: kelch-like ECH associated protein 1, sMaf: small Maf proteins, ARE: antioxidant response element, NQO-1: NAD(P)H quinone oxidoreductase-1, SOD: superoxide dismutase, GPX: Glutathione peroxidase 4, HO-1: heme oxygenase-1. (By Figdraw.)

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Cell Communication and Signaling

ISSN: 1478-811X