Fig. 2

Impact of Mast cells on psoriasis development. a Schematic representation of the animal study design, namely IMQ or Vaseline administration timepoints. b Representative photographs of the lesioned skin of mice from each group on Days 0, 4 and 6. c Disease severity scoring of each group, based on scaling, erythema, and skin thickness, from Day 0 to Day 6. d Representative haematoxylin & eosin staining of skin sections of mice from each group on Days 4 and 6. e Epidermal thickness measurements of skin sections for each group (n = 3). Scale bar = 100 μm. Results are representative of three independent experiments. Data are represented by mean ± SEM; * p < 0.05, ** p < 0.01, and *** p < 0.001. f and g Representative photomicrographs (10 × and 40 × magnification) of skin sections of mice from each group on Day 4, stained with ki67 (f) and CD31 (g). Red arrows indicate CD31⁺ vessels (brown). Scale bar = 100 μm