Fig. 1

Mast cells increase in psoriatic lesions. a and b Representative images of toluidine blue staining in paraffin skin sections obtained from healthy controls and patients with psoriasis (n = 4). c Representative images of toluidine blue staining in paraffin skin sections from control and IMQ-treated mice (n = 4). Red arrows indicate MCs. d Bar graph shows MCs quantitation between the two groups. Data are represented by mean ± SEM; * p < 0.05, ** p < 0.01, and *** p < 0.001. e Representative images of avidin immunostaining in paraffin skin sections from control and IMQ-treated mice. Red arrows indicate non-degranulated MCs, white arrows indicate degranulated MCs. Scale bar = 100 μm