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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Platelet-derived microparticles stimulate the invasiveness of colorectal cancer cells via the p38MAPK-MMP-2/MMP-9 axis

Fig. 2

PMPs transfer platelet-specific antigens and stimulate the expression of integrin subunits. A Representative confocal microscopy images of β3 (anti-CD61 Ab, red) detection in HT29, SW480 and SW620 cells not treated (left) or incubated (right) with PMPs labelled with PKH67 (green) dye. B, C flow cytometry analysis (presented as in Fig. 1) of integrin subunits (β3, αIIb, α2, α6, αv, and β4) and glycoprotein Ib on the surface of CRC cells incubated with PMPs compared to control cells (100%—dash horizontal bar). Significance was estimated as presented in Fig. 1, **P < 0.01, *P < 0.05, N = 5

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