Fig. 6
From: FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation
LRP1 is a major mediator of the suppressing metastatic role by FUT2. A Downregulation of LRP1 mRNA in CRC tissues than normal tissues in TCGA dataset. B LRP1 IP on cell lysates of HCT116 cells stably overexpressing FUT2 or control vector and transfected with NC or LRP1 shRNA. Anti-LRP1 immunoprecipitates were blotted with UEA-I or α-LRP1. C Transwell migration and invasion assays by HCT116 cells stably overexpressing FUT2 or control vector and transfected with NC or LRP1 shRNA. D–E Quantification of C. F β-catenin and vimentin levels in HCT116 cells stably overexpressing FUT2 or control vector and transfected with NC or LRP1 shRNA were assessed by western blot. G Quantification of F