Fig. 7
From: PcTrim prevents early infection with white spot syndrome virus by inhibiting AP1-induced endocytosis
Model of the PcTrim-mediated antiviral mechanism. In the early stage of WSSV infection in crayfish cells, Trim, which localizes to the membrane, recognizes the WSSV protein VP26 and binds AP1 to inhibit AP1 entry into the nucleus. Activated AP1 enhances the expression of the phagocytosis-related protein dynamin, a host protein on which WSSV invasion depends, thereby promoting the early replication of WSSV