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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation

Fig. 5

Effect of SMILE on germinal center (GC) B cell formation and signaling pathway in the spleen tissue of SMILE Tg mice. A The median fluorescence intensity (MFI) of SMILE, AMPK, and mTOR in CAIA C57BL/6 mice spleen and SMILE Tg mice spleen respectively. B B220+PNA+ GC B cells was analyzed by immunofluorescence. There was no significant difference in CD3, however, the expression of B220 and PNA was significantly decreased in SMILE Tg. C The phosphorylated (pSTAT3) 727 and pSTAT3 705 expression were decreased in SMILE Tg mice. Original magnification in 200×

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Cell Communication and Signaling

ISSN: 1478-811X