Fig. 3

SMILE regulates the proportions of Th17 and Treg cells in CIA mice treated with the SMILE vector. A Immunofluorescence data of spleen cryosections from CIA mice administered a mock or SMILE vector using confocal microscopy. The sections were stained for CD4 and IL-17 (Th17 cells) or CD4, CD25, and Foxp3 (Treg cells) (original magnification, 200×). B Flow cytometry data of FoB cells (CD23⁺CD21^low in B220 cells), MZB cells (CD23^lowCD21⁺ in B220 cells), mature B cells (IgD^high IgM^low in B220 cells), immature B cells (IgD^low IgM^high in B220 cells), and B regulatory cells (CD5⁺CD1d^high in CD19 cells) in CIA mice administered a mock or SMILE vector. Every dots represent 1 mouse respectively