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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress

Fig. 4

In vivo results of estrogenic adaptive regulation of CD73/adenosine axis via PI3K/Akt pathways during CCS. A–D Representative immunoblots and graphical presentations of cleaved caspase 3, PI3K, p-PI3K and Akt, p-Akt, were assessed from Mice. S = Sham; S + I = Sham + ISO; O = OVX; O + I = OVX + ISO; O + E, OVX + E2; O + E + I = OVX + ISO + E2. E–H In vitro results of inhibition of PI3Kby LY294002. Representative immunoblots and graphical presentations of, PI3K, p-PI3K, Akt, p-Akt and CD73. I, J Representative immunofluorescence and plotted average values of CC3 expression. Data are presented as mean ± SEM; ***p < 0.001; **p < 0.01; *p < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X