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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress

Fig. 2

Effect of E2 on CD73/adenosine axis: A–C Representative immunoblots, graphical presentations of CD73 expression and ELISA analysis of Extracellular Adenosine level (n = 6–7 mice/group). S = Sham; S + I = Sham + ISO; O = OVX; O + I = OVX + ISO; O + E, OVX + E2; O + E + I = OVX + ISO + E2. D Representative immunofluorescence of CD73expression, nuclei (DAPI) E The plotted average values of CD73 expression from each group (n = 100–150 cells per dish per 4–6 repeats per treatment group). Color channels were adjusted in the merged images to enhance the visualization of all the respective fluorescence dyes. F Analysis Adenosine activity. Data were analyzed using One –way and Two-way ANOVA, followed by Tukey’s post hoc analysis. ***p < 0.001; **p < 0.01; *p < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X