Fig. 2
From: CircRNAs: versatile players and new targets in organ fibrosis
The biogenesis, transportation, degradation and functions of circRNA. The left panel describes the three mechanisms of biogenesis of circRNAs, including complementary base-pairing driven, RBP-driven and lariat-driven circularization. The middle panel illustrates the transportation and degradation of circRNAs. The right panel briefly summarizes the modes of action of circRNAs. DDX39A DEAD-box protein 39 A, EPO4 Exportin 4, G3BP1 Ras-GTPase-activating SH3 domain-binding-proteins 1, UPF1 Upframeshift 1, RISC RNA-induced silencing complex, Ago Argonaute, TRBP Transactivation response (TAR) RNA-binding protein, YTHDF YTH domain family, HRSP12 heat responsive protein 12, RBP RNA binding protein