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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein

Fig. 6

LATS1 functions as a crucial mediator of WWP2 to promote GC cell proliferation and invasion. A, B The protein expression of WWP2, LATS1, YAP1, p-YAP and its downstream target genes, CTGF and CYR61, was detected by western blotting analysis in WWP2-silenced HGC-27 cells co-transfected with or without LATS1 siRNA. C, D Colony formation experiments were performed in WWP2-silenced HGC-27 cells co-transfected with or without LATS1 siRNA. E–H The invasive and migrative abilities were analyzed in WWP2-silenced HGC-27 cells co-transfected with or without LATS1 siRNA by transwell E, F or wound healing assays G, H, respectively. One-way ANOVA: *p < 0.05, **p < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X