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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein

Fig. 4

WWP2 knockdown suppresses the aggressive behaviors of GC cells. A, B BGC-823 and MGC-803 cells were transfected with WWP2-shRNAs, and the efficiency was validated by western blotting and qRT‒PCR assays. C CCK-8 assays were performed to detect cell growth upon WWP2 downregulation. D, E Colony formation experiments were used to analyze the effects of WWP2 silencing on cell colony formation. F–J Transwell invasion and wound healing assays were utilized to assess the invasive and migrative abilities of gastric cancer cells transfected with WWP2-shRNAs or scramble shRNA. One-way ANOVA: *p < 0.05, **p < 0.01

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Cell Communication and Signaling

ISSN: 1478-811X