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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway

Fig. 5

Daph treatment reduced apoptosis and pyroptosis in LPS-induced lung injury. a-c The mRNA expression of Caspase-3, Bax and Bcl-2 in lung tissue were detected by RT-qPCR. d-f The protein expression of pro caspase-3, cleaved caspase-3, Bax, Bcl-2, NLRP3, ASC, pro caspase-1, cleaved caspase-1, GSDMD, IL-1β, IL-18 were detected by Western blot analysis, and relative expression of previous protein were quantified by Image J software and GAPDH was acted as an internal control. All results were expressed as the means ± SD of three independent experiments. **P < 0.01 versus the control group; ##P < 0.01 versus LPS group

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Cell Communication and Signaling

ISSN: 1478-811X