Fig. 11

Blockade of CD38 exacerbated the activation of apoptosis and pyroptosis induced by LPS in MLE-12 cells. a-c The protein expression of pro caspase-3, cleaved caspase-3, Bax, Bcl-2, NLRP3, ASC, pro caspase-1, cleaved caspase-1, GSDMD, IL-1β, IL-18 were detected by Western blot analysis, and relative expression of previous protein were quantified by Image J software and GAPDH was acted as an internal control. All results were expressed as the means ± SD of three independent experiments. **P < 0.01 versus the control group; $$P < 0.01, ##P < 0.01 versus LPS group; &&P < 0.01 versus LPS + Daph group