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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL

Fig. 8

Inhibition of p-STAT6 improves the sensitivity of Ph+ ALL cells to IM. a The combined effect of AS1517499 and IM on the viability of BP190 and SUP-B15 cells was evaluated by CCK-8 assay. b The combination index of AS1517499 and IM was determined by CompuSyn software in BP190 and SUP-B15 cells. c The IC50 values of IM combined with a particular concentration of AS1517499 in BP190 and SUP-B15 cells were analyzed by CCK-8 assay. d Schematic diagram of the function and mechanisms for inhibiting STAT6 activation in Ph+ ALL cells. In Ph+ ALL induced by P190BCR-ABL, the Jak2/STAT6 pathway is activated. Inhibition of STAT6 activation promotes cell apoptosis and suppresses cell proliferation by inhibiting c-Myc transcription. **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X