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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL

Fig. 7

STAT6 is activated by Jak2 not through the classical cytokine pathway. a Concentration of cytokines in the supernatant of BP210, BP190, K562, and SUP-B15 cell culture medium were detected by FCM. In BP210, BP190, K562, and SUP-B15 cells, b the expression of Jak1, Jak2, and Jak3 was measured by western blot assay; c the mRNA of Jak2 was measured by qRT-PCR assay; d the expression of p-Jak2 was measured by western blot assay. e The expression of Jak2, p-Jak2, and p-STAT6 was measured by western blot assay after treatment with Jak2 inhibitor Fedratinib for 48 h. *p < 0.05

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Cell Communication and Signaling

ISSN: 1478-811X