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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL

Fig. 5

Inhibition of p-STAT6 suppresses the leukemogenesis of P190 but not P210 in vivo. a Appearance of liver, spleen, and lung of diseased mice. b Leukemic infiltration in the heart, liver, spleen, lung, and kidney was analyzed by HE staining, scale bar, 5 μm. c Leukemic infiltration in the heart, liver, spleen, lung, kidney, and BM was analyzed by Wright’s staining, the stab or segmented granulocytes in P210 group and immature lymphocytes in P190 group were indicated by red arrows, scale bar, 5 μm. d The expression of BCR-ABL was measured by IF assay, scale bar, 10 μm. Data are presented as the means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns indicates no significant differences

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Cell Communication and Signaling

ISSN: 1478-811X