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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL

Fig. 4

Inhibition of p-STAT6 promotes the apoptosis and differentiation in Ph+ ALL cells. After treatment with different concentrations of AS1517499 for 48 h, a cell apoptosis was measured by FCM, and b the cell apoptosis rate was analyzed; data are shown as mean ± SD(n = 3); c apoptotic morphology was assessed by DAPI staining, and the typical apoptotic cells were indicated by red arrows, scale bar, 10 μM; d the expression of PARP and Cle-caspase-3 was measured by western blot assay; e the expression of CD19, CD20, CD38, and CD138 in SUP-B15 cells and CD15, CD114, CD116, CD117 in K562 cells were detected by FCM. **p < 0.01, ****p < 0.0001. ns indicates no significant differences

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Cell Communication and Signaling

ISSN: 1478-811X