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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL

Fig. 3

Inhibition of p-STAT6 suppresses the proliferation in Ph+ ALL cells more obvious than in Ph+ CML cells. Each indicated cell line treated with different concentrations of AS1517499 for 48 h, a cell viability was evaluated by CCK-8 assay; b cell proliferation was evaluated by cell counting assay; c cell cycle distribution was analyzed by FCM. d The self-renewal ability of BP190 and SUP-B15 cells treated with different concentrations of AS1517499 for seven days were evaluated by colony formation assay. e The colony numbers of three holes in each group were analyzed. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns indicates no significant differences

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Cell Communication and Signaling

ISSN: 1478-811X