Fig. 1

P190 induces more aggressive leukemia than P210 in mice. a Representative diseased mice in P210 and P190 groups were photographed for comparison. b Representative liver, spleen, and lung in groups of healthy control, BP210, and BP190 were photographed for comparison. The weights of (c) liver, (d) spleen, and (e) lung were measured and analyzed. f The maximum WBC counts of mice were determined and analyzed (The dynamic WBC counts were absent because two mice in the P190 control group and one in the P210 treated group died prematurely). The mice’s weight changes from the beginning to the end in the (g) P210 and (h) P190 group were graphed. i The infiltration of leukemic cells in the heart, liver, spleen, lung, kidney, and BM was analyzed by Wright’s staining, the stab or segmented granulocytes cells in P210 group and immature lymphocytes in P190 group were indicated by red arrows, scale bar, 5 μM. j Kaplan–Meier survival analysis of mice. ***p < 0.001, ****p < 0.0001. ns indicates no significant differences