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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: CEBPα/miR-101b-3p promotes meningoencephalitis in mice infected with Angiostrongylus cantonensis by promoting microglial pyroptosis

Fig. 3

Pyroptosis in the brains of A. cantonensis–infected mice was decreased after miR-101b-3p inhibition. A–C The inflammatory infiltration caused by A. cantonensis infection was decreased after miR-101b-3p inhibition. D TUNEL staining indicating cell death in the brain was decreased after miR-101b-3p inhibition. E Transcriptome data showed the changes of apoptosis-related genes (BCL2, Bax, Caspase3, Caspase7, c-Myc, LATS1, Mcl1, and YAP1) and pyroptosis-related genes (NLRP3, IL-1β, Gasdermin-D, and ASC). F Western blotting revealed that pyroptosis proteins (Caspase1, NLRP3, GSDMD, IL-1β, and IL-18) were up-regulated in the brain after A. cantonensis infection. G Immunofluorescence showed that NLRP3 and cleaved IL-1β were down-regulated after miR-101b-3p TuD

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Cell Communication and Signaling

ISSN: 1478-811X