Fig. 6

Regular exercise increased mitochondrial Ahi1 and GR levels and ATP levels in the brains of Dex-treated mice. Mice were divided into NS, NS + Exe, Dex, and Dex + Exe groups. Regular exercise lasted for 4 weeks, and behaviors were measured every week. Immobility time in the tail suspension test (TST) and forced swimming test (FST) were examined. N = 10–11 mice (a, b). A sucrose preference test was performed and the percentage of sucrose consumed in the total drinking water was calculated. N = 10–11 mice (c). The weights of the mice were recorded for 4 weeks, and a weight growth curve was drawn. N = 10–11 mice (d). After 4 weeks of exercise, ATP levels were measured in the cortex (CTX), hypothalamus (HY), hippocampus (Hi), and cerebellum (CB) of four groups of mice. N = 5 mice (e). Western blot analysis showed the expression of Ahi1 and GR in the mitochondria of hypothalamic tissue in the four groups. N = 5 mice (f, g). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001