Fig. 5

Exogenous ATP had rapid antidepressant-like effects in Ahi1 KO mice. Ahi1 KO mice were intraperitoneally injected with ATP (125 mg/kg) and the antidepressant imipramine (IM, 20 mg/kg) for 3 weeks. Immobility time in the tail suspension test (TST) and forced swimming test (FST) were examined in control mice and Ahi1 KO mice. N = 9 mice (a, b). A sucrose preference test was performed, and the percentage of sucrose consumed in the total drinking water was calculated. N = 9 mice (c). Body weight was recorded from the day of administration of Ahi1 KO mice for 3 weeks, and a growth curve of body weight was drawn. N = 9 mice (d). *P < 0.05, **P < 0.01, ***P < 0.001