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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice

Fig. 4

Mitochondrial GR and TFAM bound to the D-loop region of mtDNA and regulated mtDNA copy numbers. TFAM mRNA levels in the hypothalamus of Ahi1 KO mice were detected by qPCR. N = 5 mice (a). The TFAM in the hypothalamic mitochondria of the Ahi1 KO mice was detected by Western blotting. N = 6 mice (b, c). Relative GR and TFAM binding to the mtDNA D-loop region in the hypothalamus of Ahi1 KO mice was detected by ChIP/qPCR. N = 5 mice (d, e). **P < 0.01, ***P < 0.001, ****P < 0.0001

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Cell Communication and Signaling

ISSN: 1478-811X