Skip to main content
Fig. 1 | Cell Communication and Signaling

Fig. 1

From: The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice

Fig. 1

Ahi1 deficiency reduced cellular ATP and mitochondrial GR levels. ATP levels were measured in the cortex (CTX), hypothalamus (HY), hippocampus (Hi), and cerebellum (CB) in control mice and Ahi1 KO mice. N = 6 mice (a). Western blot analysis showed the expression of Ahi1 and GR in the mitochondria of hypothalamic tissues in control mice and Ahi1 KO mice. N = 6 mice (b, c). PC12 cells were transfected with Ahi1-siRNA or GR-siRNA, and ATP levels were detected 48 h after transfection. N = 6 cell samples (d, e). PC12 cells were transfected with Ahi1-siRNA for 48 h, and the levels of mitoATP, glycoATP, and total ATP production rates were detected. N = 10 cell samples (f). **P < 0.01, ***P < 0.001, ****P < 0.0001

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X