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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair

Fig. 9

Schematic demonstrating that Cth can activate the ERK1/2 signalling pathway, induce macrophage efferocytosis, and promote intestinal barrier repair. Macrophages are recruited to the site of intestinal injury, and Cth activates the ERK1/2 signalling pathway in macrophages, which in turn induces macrophage phagocytosis of apoptotic endothelial cells, inhibits the release of the proinflammatory factors IL-6 and TNF-α, and promotes the secretion of SPMs (Lipoxin A4, RvD1, RvE1) and the anti-inflammatory factor IL-10, thereby helping to restore intestinal barrier function

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Cell Communication and Signaling

ISSN: 1478-811X