Fig. 4
From: The Warburg effect modulates DHODH role in ferroptosis: a review
Warburg effect and its modulation of the anti-ferroptosis function of DHODH. A In the absence of functional complexes I and II, DHODH sustains the ETC and O2− generation by shuttling electrons to complex III. Complex III-generated O2− induces oxidative stress that results in ferroptosis. B When complexes I and II of the ETC are inhibited by the Warburg effect, DHODH inhibition could cause a complete shutdown of the ETC resulting in the failure of complex III to produce O2−. Differences between A and B has been highlighted in yellow