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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: The Warburg effect modulates DHODH role in ferroptosis: a review

Fig. 3

Role of DHODH and complex III in tumor growth. DHODH-catalyzed reaction is the rate-limiting step in de novo pyrimidine nucleotide biosynthesis. It catalyzes the conversion of dihydroorotate to orotate used for nucleic acid biosynthesis. This reaction needs the activity of complex III of the ETC and it involves the conversion of ubiquinol (COQ-e-) to ubiquinone (COQ)

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Cell Communication and Signaling

ISSN: 1478-811X