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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The Warburg effect modulates DHODH role in ferroptosis: a review

Fig. 2

A Ferroptosis inhibition by DHODH. DHODH-generated Ubiquinol (COQ-e-) reduces mitochondrial membrane phospholipids hydroperoxides to lipids alcohol, thereby inhibiting the onset of ferroptosis. B Ferroptosis induction by DHODH. DHODH-catalyzed reaction indirectly reduces the cellular level of GSH. This is because the nucleoside triphosphates (NTPs) it produces are required for RNR-catalyzed reaction which uses GSH as a cofactor. This can inhibit GPX4 via GSH depletion

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Cell Communication and Signaling

ISSN: 1478-811X