Fig. 1

Sema7a^R145W homozygous mice displayed inflammation accompanied by elevated inflammatory cytokines. a Representative images of H&E staining in wild-type and Sema7a^R145W homozygous male mice at 8 weeks of age. b Analysis of portal inflammation infiltration in H&E-stained liver sections of wild-type (n = 4) and Sema7a^R145W homozygous male mice (n = 5). c The relative levels of mRNA transcripts of TNFα and IL1β in liver tissues of wild-type (n = 4) and Sema7a^R145W homozygous male mice (n = 5) and d in primary hepatocytes from wild-type (n = 3) and Sema7a^R145W homozygous (n = 3) male mice. e, g Western blotting analysis of the relative levels of TNFα and IL1β protein expression in the liver of wild-type (n = 4) and Sema7a^R145W homozygous male mice (n = 5) and f, h in primary hepatocytes from wild-type (n = 3) and Sema7a^R145W homozygous (n = 3) male mice. The data were analysed by the independent-samples Student’s t test. * means p < 0.05 versus wild-type mice