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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC

Fig. 9

Activation of AMPK up-regulates SLC7A2 expression in NSCLC cells. A treatment with metformin reduced the clone formation in both A549-WT and A549-DDP-R cells (magnification × 100). B Treatment with metformin and/or cisplatin inhibited the proliferation of H460-WT cells. C, D Treatment with either metformin or AICAR activated AMPK and up-regulated SLC7A2 expression in A549-WT and H460-WT cells. E, F The relative E2F1 mRNA expression in H460-shRNA-SLC7A2 and A549-shRNA-SLC7A2 cell lines. G the Co-IP assay was performed with H460 cells. And we used E2F1 primary antibody as IP antibody and SLC7A2 primary antibody as IB antibody

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Cell Communication and Signaling

ISSN: 1478-811X