Fig. 9From: NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosisSchematic model for NEDD4 inhibiting NLRP3 inflammasome activation medicated pyroptosis. In macrophages, the constitutively expressed NEDD4 indirectly binds to NLRP3 through SF3A2, indirectly promotes proteasomal degradation of NLRP3 by regulating SF3A2 ubiquitination, and maintains NLRP3 low expression, which inhibits cell pyroptosisBack to article page