Fig. 1
From: NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis
NEDD4 alleviates myocardial reperfusion injury in mice. A Representative TTC-Evan’s Blue stained sections of heart from each group. Brick red-stained area represents the area at risk (AAR), whereas the white area indicates the infarcted size (IS). B, C Ratio of AAR/LV, IS/ARR. Data are expressed as mean ± SD (n=10 for each). *P < 0.05 vs. NEDD4+/++I/R group. D Representative cross-sectional images of the left ventricular (LV) showing no-reflow regions indicated by the absence of thioflavin-S fluorescence within the ischemic area that consists of both no-reflow (yellow arrows) and reflow zones (green arrows) following IR. E Ratio of no reflow area/LV. Data are expressed as mean ± SD (n=10 for each). *P < 0.05 vs. NEDD4+/++I/R group. F Survival analysis for mice subjected to 45 min ischemia and following 6 h perfusion (*P < 0.05 vs. NEDD4+/++I/R group, log-rank test for survival analysis). G Effect of NEDD4 on cell pyroptosis. H Quantitative analysis of pyroptosis cells was performed. *P < 0.05 vs. NEDD4+/++I/R group