Table 3 The biological role of miR-20b in various cancer and its targets
From: The dual role of microRNA (miR)-20b in cancers: Friend or foe?
Type of cancer | Levels in tumor | Biological process | Target gene | Description of target gene | References |
|---|---|---|---|---|---|
Breast | Increased | Proliferation and cell cycle | PTEN and BRCA1 | Tumor suppressor | [61] |
Decreased | Metastasis | VEGF | Angiogenesis | [62] | |
Increased | Autophagy | RB1CC1/FIP200 | Autophagosome formation-related proteins | [63] | |
Increased | Proliferation and cell cycle | CCND1 and E2F1inhibitors | Tumor suppressor | [64] | |
Ovarian | Increased | Apoptosis | Bcl2 | Anti-apoptotic | [65] |
Decreased | cell cycle | Cyclin D | Oncogene | [66] | |
Prostate | Increased | proliferation and cell cycle | PTEN | Tumor suppressor | [67] |
Decreased | Metastasis | TGFBR2 | Oncogene | [68] | |
Cervical | Increased | Metastasis | TIMP-2 | MMPs inhibitor | [69] |
Lung | Increased | Proliferation and cell cycle | BTG3 | An anti-proliferative protein | [70] |
Esophageal | Increased | Metastasis | PTEN | Tumor suppressor | [71] |
Colon | Increased | Drug resistance | ADAM9 | MMPs activator | [72] |
Increased | Metastasis | Oct4 and MALAT1 | Cancer stem cell regulators | [73] | |
Increased | Migration and invasion | PTEN | Tumor suppressor | [74] | |
Decreased | Drug resistance | Syndecan-2 | Promote cell survival | [75] | |
Bladder | Decreased | Metastasis | MMP2 | Oncogene | [76] |
Decreased | Proliferation | CDK6, CDK2, and cyclin D | Cell cycle-regulated genes | [76] | |
Thyroid | Decreased | Proliferation | Sos1 and ERK2 | Oncogene | [77] |
Decreased | Apoptosis | DUXAP8 | As long non-coding RNA | [78] | |
Liver | Increased | Proliferation | PTEN | Tumor suppressor | [79] |
Decreased | Drug resistance | CDC37L1 | A cochaperone protein leading to cell survival | [80] | |
Increased | Angiogenesis | STAT3 | Suppress VEGF expression | [81] | |
kidney | Decreased | Apoptosis | MAPK | Inhibit apoptosis | [82] |
Gastric | Decreased | Drug resistance | HIF1A | Up-regulates drug resistance-related genes | [83] |
Endometrial | Decreased | EMT | HIF-1 alpha | Induce hypoxia | [84] |