The dual role of microRNA (miR)-20b in cancers: Friend or foe?

Table 1 The miR-20b role in modulating the biological function of human cells

Cell type	Biological process	Signal pathway	Target genes	Potential diseases	References
Vascular smooth muscle cells	Blood pressure	–	MAGI3	Hypertension	[25]
Endothelial cells	Autophagy	HIF-1	ULK1	–	[26]
Placental trophoblast cells	Viability	–	MCL-1	Preeclampsia	[27]
Smooth muscle cells	Proliferation	STAT3	PDGF	Asthma	[28]
Trophoblast cell	Migration	–	MMP-2	Preeclampsia	[29]
T Cell	Proliferation and Activation	NFAT	NFAT5 and CAMTA1	Myasthenia Gravis	[30]
Mesenchymal stem cells	Differentiation	Notch	Ngn2, MAP2, and TUBB3	–	[31]
Lung tissues cells	Apoptosis	Mitochondrial intrinsic pathway	MFN1 and MFN2	Lung injury	[32]
Cardiac cell	Apoptosis and Differentiation	BMP	–	Heart diseases	[33]
Chondrocyte	Proliferation and autophagy	PI3K/AKT/mTOR	ATG10	Osteoarthritis	[34]
Neurons	Differentiation	WNT	NRSF/REST	Neurological disorders	[35]
Macrophage-derived foam cells	Cholesterol metabolism	–	ABCA1	Atherosclerosis	[36]
pluripotent stem cells	Apoptosis	Intrinsic pathway	BIM	–	[37]
Hematopoietic stem cell	Differentiation	–	MAFB	–	[38]
Macrophage and kidney	Lipid metabolism	Epigenetic pathways	ABCA1, ABCG1, and SCARBI	Atherosclerosis	[39]
Multipotent Stromal Cells	Cell cycle and DNA synthesis	–	p21, CCND1, and E2F1	–	[40]
Human umbilical vein endothelial cells	Cell senescence	Wnt/beta-catenin	TXNIP	Cardiovascular disease	[41]
Cardiomyocytes	Apoptosis	NF-kappa B	HIF-1 alpha	Cardiovascular disease	[23]

ISSN: 1478-811X