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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: (Pro)renin receptor promotes colorectal cancer progression through inhibiting the NEDD4L-mediated Wnt3 ubiquitination and modulating gut microbiota

Fig. 5

Wnt3 is up-regulated and Wnt3-NEDD4L colocalization is down-regulated in the gut epithelium of ATP6AP2 WT/KI mice. A Representative IHC staining images of (P)RR and Wnt3 in the gut epithelium of ATP6AP2 WT/KI mice and wildtype mice. B Representative images of IF detecting the Wnt3-NEDD4L colocalization in the gut epithelium of ATP6AP2 WT/KI mice and wildtype mice. Red color indicates NEDD4L protein staining. Green color indicates Wnt3 protein staining. Blue color indicates nulus stained by DAPI. Yellow color indicated by white arrows represents the merged red and green colors, namely Wnt3-NEDD4L colocalization. DAPI: 4',6-diamidino-2-phenylindole

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Cell Communication and Signaling

ISSN: 1478-811X