The roles of connexins and gap junctions in the progression of cancer

Table 1 Coding genes and tissue distribution of connexins (Cxs)

Gene	Cx	Expression in normal human tissue
GJA1	Cx43	Cardiac [29], lung [30], skin [31]
GJA3	Cx46	Cartilage [32], lens [33]
GJA4	Cx37	Spinal cord [34], ovary [35]
GJA5	Cx40	Spinal cord [34]
GJA8	Cx50	Lens [33]
GJA9	Cx59	Retina [36]
GJA10	Cx62	Platelets [37]
GJB1	Cx32	Liver [38, 39], cartilage [32], oligodendrocytes [40]
GJB2	Cx26	Liver [38, 39], astrocytes [40], cochlea [41]
GJB3	Cx31	Cochlea [41]
GJB4	Cx30.3	Thymus [42]
GJB5	Cx31.1	Trophoblast cells [43], epidermis [44, 45]
GJB6	Cx30	Astrocytes [46]
GJB7	Cx25	Hematopoietic stem cells [47]
GJC1	Cx45	Cardiac cells [48]
GJC2	Cx47	Astrocytes [49], oligodendrocytes [49]
GJC3	Cx30.2/31.3	Oligodendrocytes [50]
GJD2	Cx36	Retina [51]
GJD3	Cx31.9	Cardiac cells [52]
GJD4	Cx40.1	Skeletal muscle [53]
GJE1	Cx23	Lens [54]

The first two columns were compiled from NCBI (National Center for Biotechnology Information (nih.gov)) data. Currently, 21 types of Cxs are known. The expression of each type of Cx in the human body is spatially different. The third column provides examples of the distribution of Cxs in normal human tissue

ISSN: 1478-811X