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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Fusobacterium nucleatum triggers proinflammatory cell death via Z-DNA binding protein 1 in apical periodontitis

Fig. 6

Inhibition of pyroptosis and necroptosis reduces the production of inflammatory cytokines. A mRNA levels of Il1b, Il6, Tnf and Cxcl10 in RAW264.7 cells cocultured with F. nucleatum (MOI = 50) for 12 h after transfection with siGSDME, siMLKL or siRIPK3 for 48 h (NC, negative control; one-way ANOVA). B mRNA levels of Il1b, Il6, Tnf and Cxcl10 in RAW264.7 cells cocultured with F. nucleatum (MOI = 50) for 12 h after treatment with the DEVD caspase-3 inhibitor at 5, 10, 20, and 50 µM (one-way ANOVA). C, E Diameter distribution and morphology of F. nucleatum-EVs. D Zeta potential of F. nucleatum-EVs. F Images of nuclei of RAW 264.7 and Dio-labeled F. nucleatum-EVs (green) after internalization by RAW 264.7 cells. Data are expressed as the mean ± SEM (*p < 0.05; **p < 0.01; ***p < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X